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Inositol-requiring enzyme 1α links palmitate-induced mTOR activation and lipotoxicity in hepatocytes
Hepatic lipotoxicity, hepatocyte dysfunction/cell death induced by saturated fatty acids (SFA), plays a central role in the pathogenesis of nonalcoholic fatty liver disease (NAFLD); however, the underlying mechanisms remain unclear. Palmitate is the most abundant SFA in the circulation. In this stud...
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| Publicado no: | Am J Physiol Cell Physiol |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Physiological Society
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7792676/ https://ncbi.nlm.nih.gov/pubmed/33052067 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00165.2020 |
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