Gut Metabolite TMAO Induces Synaptic Plasticity Deficits by Promoting Endoplasmic Reticulum Stress

Dysbiosis of gut microbiota is strongly associated with metabolic diseases including diabetes mellitus, obesity, and cardiovascular disease. Recent studies indicate that Trimethylamine N-oxide (TMAO), a gut microbe-dependent metabolite is implicated in the development of age-related cognitive declin...

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Veröffentlicht in:Front Mol Neurosci
Hauptverfasser: Govindarajulu, Manoj, Pinky, Priyanka D., Steinke, Ian, Bloemer, Jenna, Ramesh, Sindhu, Kariharan, Thiruchelvan, Rella, Robert T., Bhattacharya, Subhrajit, Dhanasekaran, Muralikrishnan, Suppiramaniam, Vishnu, Amin, Rajesh H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2020
Schlagworte:
Neuroscience
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7437142/
https://ncbi.nlm.nih.gov/pubmed/32903435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2020.00138
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