Cisplatin inhibits SIRT3-deacetylation MTHFD2 to disturb cellular redox balance in colorectal cancer cell

The folate-coupled metabolic enzyme MTHFD2 (the mitochondrial methylenetetrahydrofolate dehydrogenase/cyclohydrolase) confers redox homeostasis and drives cancer cell proliferation and migration. Here, we show that MTHFD2 is hyperacetylated and lysine 88 is the critical acetylated site. SIRT3, the m...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Wan, Xingyou, Wang, Chao, Huang, Zhenyu, Zhou, Dejian, Xiang, Sheng, Qi, Qian, Chen, Xinyuan, Arbely, Eyal, Liu, Chen-Ying, Du, Peng, Yu, Wei
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7434776/
https://ncbi.nlm.nih.gov/pubmed/32811824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-02825-y
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