Cisplatin inhibits SIRT3-deacetylation MTHFD2 to disturb cellular redox balance in colorectal cancer cell

The folate-coupled metabolic enzyme MTHFD2 (the mitochondrial methylenetetrahydrofolate dehydrogenase/cyclohydrolase) confers redox homeostasis and drives cancer cell proliferation and migration. Here, we show that MTHFD2 is hyperacetylated and lysine 88 is the critical acetylated site. SIRT3, the m...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Cell Death Dis
Main Authors: Wan, Xingyou, Wang, Chao, Huang, Zhenyu, Zhou, Dejian, Xiang, Sheng, Qi, Qian, Chen, Xinyuan, Arbely, Eyal, Liu, Chen-Ying, Du, Peng, Yu, Wei
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7434776/
https://ncbi.nlm.nih.gov/pubmed/32811824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-02825-y
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker