Cisplatin inhibits SIRT3-deacetylation MTHFD2 to disturb cellular redox balance in colorectal cancer cell

The folate-coupled metabolic enzyme MTHFD2 (the mitochondrial methylenetetrahydrofolate dehydrogenase/cyclohydrolase) confers redox homeostasis and drives cancer cell proliferation and migration. Here, we show that MTHFD2 is hyperacetylated and lysine 88 is the critical acetylated site. SIRT3, the m...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Cell Death Dis
Autors principals: Wan, Xingyou, Wang, Chao, Huang, Zhenyu, Zhou, Dejian, Xiang, Sheng, Qi, Qian, Chen, Xinyuan, Arbely, Eyal, Liu, Chen-Ying, Du, Peng, Yu, Wei
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7434776/
https://ncbi.nlm.nih.gov/pubmed/32811824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-02825-y
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars