Investigation of the Drug Resistance Mechanism of M2-S31N Channel Blockers through Biomolecular Simulations and Viral Passage Experiments

[Image: see text] Recent efforts in drug development against influenza A virus (IAV) M2 proton channel S31N mutant resulted in conjugates of amantadine linked with aryl head heterocycles. To understand the mechanism of drug resistance, we chose a representative M2-S31N inhibitor, compound 3, as a ch...

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Udgivet i:ACS Pharmacol Transl Sci
Main Authors: Musharrafieh, Rami, Lagarias, Panagiotis, Ma, Chunlong, Hau, Raymond, Romano, Alex, Lambrinidis, George, Kolocouris, Antonios, Wang, Jun
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2020
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7432665/
https://ncbi.nlm.nih.gov/pubmed/32832869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsptsci.0c00018
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