Inactivation of Endothelial ADAM17 Reduces Retinal Ischemia-Reperfusion Induced Neuronal and Vascular Damage

Retinal ischemia contributes to visual impairment in ischemic retinopathies. A disintegrin and metalloproteinase ADAM17 is implicated in multiple vascular pathologies through its ability to regulate inflammatory signaling via ectodomain shedding. We investigated the role of endothelial ADAM17 in neu...

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Publicado en:Int J Mol Sci
Autores principales: Gutsaeva, Diana R, Shalaby, Lamiaa, Powell, Folami L, Thounaojam, Menaka C, Abouhish, Hossameldin, Wetzstein, Sara A, Jadeja, Ravirajsinh N, Kwok, Hang Fai, Martin, Pamela M, Bartoli, Manuela
Formato: Artigo
Lenguaje:Inglês
Publicado: MDPI 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7432237/
https://ncbi.nlm.nih.gov/pubmed/32751103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21155379
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