Role of Endothelial ADAM17 in Early Vascular Changes Associated with Diabetic Retinopathy

ADAM17, a disintegrin and metalloproteinase 17, is a transmembrane metalloproteinase that regulates bioavailability of multiple membrane-bound proteins via ectodomain shedding. ADAM17 activity was shown to contribute to a number of vascular pathologies, but its role in the context of diabetic retino...

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Detalhes bibliográficos
Main Authors: Lamiaa Shalaby, Menaka Thounaojam, Amany Tawfik, Junnan Li, Khaled Hussein, Wan Jin Jahng, Mohamed Al-Shabrawey, Hang Fai Kwok, Manuela Bartoli, Diana Gutsaeva
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2020-02-01
Colecção:Journal of Clinical Medicine
Assuntos:
diabetic retinopathy
a disintegrin and metalloproteinase 17
endothelial cells
vascular inflammation
vascular permeability
Acesso em linha:https://www.mdpi.com/2077-0383/9/2/400
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