MicroRNA-34a (miR-34a) Mediates Retinal Endothelial Cell Premature Senescence through Mitochondrial Dysfunction and Loss of Antioxidant Activities

Stress-associated premature senescence (SAPS) is involved in retinal microvascular injury and diabetic retinopathy. We have investigated the role and mode of action of miR-34a in retinal endothelial cells senescence in response to glucidic stress. Human retinal microvascular endothelial cells (HuREC...

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Veröffentlicht in:Antioxidants (Basel)
Hauptverfasser: Thounaojam, Menaka C., Jadeja, Ravirajsinh N., Warren, Marie, Powell, Folami L., Raju, Raghavan, Gutsaeva, Diana, Khurana, Sandeep, Martin, Pamela M., Bartoli, Manuela
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6769710/
https://ncbi.nlm.nih.gov/pubmed/31443378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/antiox8090328
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