Loss of NAMPT in aging retinal pigment epithelium reduces NAD(+) availability and promotes cellular senescence

Retinal pigment epithelium (RPE) performs numerous functions critical to retinal health and visual function. RPE senescence is a hallmark of aging and degenerative retinal disease development. Here, we evaluated the temporal expression of key nicotinamide adenine dinucleotide (NAD(+))-biosynthetic g...

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Bibliografiske detaljer
Udgivet i:Aging (Albany NY)
Main Authors: Jadeja, Ravirajsinh N., Powell, Folami L., Jones, Malita A., Fuller, Jasmine, Joseph, Ethan, Thounaojam, Menaka C., Bartoli, Manuela, Martin, Pamela M.
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals 2018
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Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6046249/
https://ncbi.nlm.nih.gov/pubmed/29905535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.101469
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