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Ureidothiophene inhibits interaction of bacterial RNA polymerase with –10 promotor element

Bacterial RNA polymerase is a potent target for antibiotics, which utilize a plethora of different modes of action, some of which are still not fully understood. Ureidothiophene (Urd) was found in a screen of a library of chemical compounds for ability to inhibit bacterial transcription. The mechani...

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Bibliographische Detailangaben
Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Harbottle, John, Zenkin, Nikolay
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2020
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7430646/
https://ncbi.nlm.nih.gov/pubmed/32652039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa591
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