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Central role of the RNA polymerase trigger loop in intrinsic RNA hydrolysis
The active center of RNA polymerase can hydrolyze phosphodiester bonds in nascent RNA, a reaction thought to be important for proofreading of transcription. The reaction proceeds via a general two Mg(2+) mechanism and is assisted by the 3′ end nucleotide of the transcript. Here, by using Thermus aqu...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2010
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2890756/ https://ncbi.nlm.nih.gov/pubmed/20534498 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0914424107 |
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