Structural, functional, and genetic analysis of sorangicin inhibition of bacterial RNA polymerase

A combined structural, functional, and genetic approach was used to investigate inhibition of bacterial RNA polymerase (RNAP) by sorangicin (Sor), a macrolide polyether antibiotic. Sor lacks chemical and structural similarity to the ansamycin rifampicin (Rif), an RNAP inhibitor widely used to treat...

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Main Authors: Campbell, Elizabeth A, Pavlova, Olga, Zenkin, Nikolay, Leon, Fred, Irschik, Herbert, Jansen, Rolf, Severinov, Konstantin, Darst, Seth A
Formato: Artigo
Idioma:Inglês
Publicado: 2005
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC549610/
https://ncbi.nlm.nih.gov/pubmed/15692574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600499
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