Bacterial RNA polymerase subunit ω and eukaryotic RNA polymerase subunit RPB6 are sequence, structural, and functional homologs and promote RNA polymerase assembly

Bacterial DNA-dependent RNA polymerase (RNAP) has subunit composition β′βα(I)α(II)ω. The role of ω has been unclear. We show that ω is homologous in sequence and structure to RPB6, an essential subunit shared in eukaryotic RNAP I, II, and III. In Escherichia coli, overproduction of ω suppresses the...

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Dades bibliogràfiques

Publicat a:	Proc Natl Acad Sci U S A
Autors principals:	Minakhin, Leonid, Bhagat, Sechal, Brunning, Adrian, Campbell, Elizabeth A., Darst, Seth A., Ebright, Richard H., Severinov, Konstantin
Format:	Artigo
Idioma:	Inglês
Publicat:	National Academy of Sciences 2001
Matèries:	Biological Sciences
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC14680/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11158566/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.98.3.892
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