Bacterial RNA polymerase subunit ω and eukaryotic RNA polymerase subunit RPB6 are sequence, structural, and functional homologs and promote RNA polymerase assembly

Bacterial DNA-dependent RNA polymerase (RNAP) has subunit composition β′βα(I)α(II)ω. The role of ω has been unclear. We show that ω is homologous in sequence and structure to RPB6, an essential subunit shared in eukaryotic RNAP I, II, and III. In Escherichia coli, overproduction of ω suppresses the...

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Bibliographic Details
Main Authors: Minakhin, Leonid, Bhagat, Sechal, Brunning, Adrian, Campbell, Elizabeth A., Darst, Seth A., Ebright, Richard H., Severinov, Konstantin
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences 2001
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC14680/
https://ncbi.nlm.nih.gov/pubmed/11158566
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