Attenuated influenza virions expressing the SARS-CoV-2 receptor-binding domain induce neutralizing antibodies in mice

An effective vaccine is essential to controlling the spread of SARS-CoV-2 virus. Here, we describe an influenza-virus-based vaccine for SARS-CoV-2. We incorporated a membrane-anchored form of the SARS-CoV-2 Spike receptor binding domain (RBD) in place of the neuraminidase (NA) coding sequence in an...

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Publicado en:bioRxiv
Autores principales: Loes, Andrea N., Gentles, Lauren E., Greaney, Allison J., Crawford, Katharine H. D., Bloom, Jesse D.
Formato: Artigo
Lenguaje:Inglês
Publicado: Cold Spring Harbor Laboratory 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7430565/
https://ncbi.nlm.nih.gov/pubmed/32817935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.08.12.248823
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