GSK973 Is an Inhibitor of the Second Bromodomains (BD2s) of the Bromodomain and Extra-Terminal (BET) Family

[Image: see text] Pan-BET inhibitors have shown profound efficacy in a number of in vivo preclinical models and have entered the clinic in oncology trials where adverse events have been reported. These inhibitors interact equipotently with the eight bromodomains of the BET family of proteins. To bet...

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Veröffentlicht in:ACS Med Chem Lett
Hauptverfasser: Preston, Alex, Atkinson, Stephen J., Bamborough, Paul, Chung, Chun-wa, Gordon, Laurie J., Grandi, Paola, Gray, James R. J., Harrison, Lee A., Lewis, Antonia J., Lugo, David, Messenger, Cassie, Michon, Anne-Marie, Mitchell, Darren J., Prinjha, Rab K., Rioja, Inmaculada, Seal, Jon, Taylor, Simon, Thesmar, Pierre, Wall, Ian D., Watson, Robert J., Woolven, James M., Demont, Emmanuel H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2020
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7429977/
https://ncbi.nlm.nih.gov/pubmed/32832027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.0c00247
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