GSK973 Is an Inhibitor of the Second Bromodomains (BD2s) of the Bromodomain and Extra-Terminal (BET) Family

[Image: see text] Pan-BET inhibitors have shown profound efficacy in a number of in vivo preclinical models and have entered the clinic in oncology trials where adverse events have been reported. These inhibitors interact equipotently with the eight bromodomains of the BET family of proteins. To bet...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Preston, Alex, Atkinson, Stephen J., Bamborough, Paul, Chung, Chun-wa, Gordon, Laurie J., Grandi, Paola, Gray, James R. J., Harrison, Lee A., Lewis, Antonia J., Lugo, David, Messenger, Cassie, Michon, Anne-Marie, Mitchell, Darren J., Prinjha, Rab K., Rioja, Inmaculada, Seal, Jon, Taylor, Simon, Thesmar, Pierre, Wall, Ian D., Watson, Robert J., Woolven, James M., Demont, Emmanuel H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2020
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7429977/
https://ncbi.nlm.nih.gov/pubmed/32832027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.0c00247
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