Signalling, trafficking and glucoregulatory properties of glucagon‐like peptide‐1 receptor agonists exendin‐4 and lixisenatide

BACKGROUND AND PURPOSE: Amino acid substitutions at the N‐termini of glucagon‐like peptide‐1 (GLP‐1) receptor agonist peptides result in distinct patterns of intracellular signalling, sub‐cellular trafficking and efficacy in vivo. Here, we to determine whether sequence differences at the ligand C‐te...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Pickford, Philip, Lucey, Maria, Fang, Zijian, Bitsi, Stavroula, de la Serna, Jorge Bernardino, Broichhagen, Johannes, Hodson, David J., Minnion, James, Rutter, Guy A., Bloom, Stephen R., Tomas, Alejandra, Jones, Ben
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7429481/
https://ncbi.nlm.nih.gov/pubmed/32436216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.15134
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