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Interception of the “Bycroft-Gowland” intermediate in the enzymatic macrocyclization of thiopeptides
Thiopeptides are a broad class of macrocyclic, heavily modified peptide natural products that are unified by the presence of a substituted, nitrogen-containing heterocycle core. Early work indicated that this core might be fashioned from two dehydroalanines by an enzyme-catalyzed aza-[4+2] cycloaddi...
Tallennettuna:
| Julkaisussa: | J Am Chem Soc |
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| Päätekijät: | , , , , , , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
2020
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7429253/ https://ncbi.nlm.nih.gov/pubmed/32609512 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.0c05639 |
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