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Structural insights into enzymatic [4+2] aza-cycloaddition in thiopeptide antibiotic biosynthesis
The [4+2] cycloaddition reaction is an enabling transformation in modern synthetic organic chemistry, but there are only limited examples of dedicated natural enzymes that can catalyze this transformation. Thiopeptides (or more formally thiazolyl peptides) are a class of thiazole-containing, highly...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2017
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5724283/ https://ncbi.nlm.nih.gov/pubmed/29158402 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1716035114 |
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