Structural insights into enzymatic [4+2] aza-cycloaddition in thiopeptide antibiotic biosynthesis

The [4+2] cycloaddition reaction is an enabling transformation in modern synthetic organic chemistry, but there are only limited examples of dedicated natural enzymes that can catalyze this transformation. Thiopeptides (or more formally thiazolyl peptides) are a class of thiazole-containing, highly...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Cogan, Dillon P., Hudson, Graham A., Zhang, Zhengan, Pogorelov, Taras V., van der Donk, Wilfred A., Mitchell, Douglas A., Nair, Satish K.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2017
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5724283/
https://ncbi.nlm.nih.gov/pubmed/29158402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1716035114
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