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Bioinformatic expansion and discovery of thiopeptide antibiotics

Thiopeptides are members of the ribosomally synthesized and posttranslationally modified peptides (RiPP) family of natural products. Most characterized thiopeptides display nanomolar potency towards Gram-positive bacteria by blocking protein translation with several being produced at the industrial...

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Publicado en:J Am Chem Soc
Autores principales: Schwalen, Christopher J., Hudson, Graham A., Kille, Bryce, Mitchell, Douglas A.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2018
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6070396/
https://ncbi.nlm.nih.gov/pubmed/29983054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b03896
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