Blockade of PAR‐1 Signaling Attenuates Cardiac Hypertrophy and Fibrosis in Renin‐Overexpressing Hypertensive Mice

BACKGROUND: Although PAR‐1 (protease‐activated receptor‐1) exerts important functions in the pathophysiology of the cardiovascular system, the role of PAR‐1 signaling in heart failure development remains largely unknown. We tested the hypothesis that PAR‐1 signaling inhibition has protective effects...

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Detaylı Bibliyografya
Yayımlandı:J Am Heart Assoc
Asıl Yazarlar: Yokono, Yoshikazu, Hanada, Kenji, Narita, Masato, Tatara, Yota, Kawamura, Yousuke, Miura, Naotake, Kitayama, Kazutaka, Nakata, Masamichi, Nozaka, Masashi, Kato, Tomo, Kudo, Natsumi, Tsushima, Michiko, Toyama, Yuichi, Itoh, Ken, Tomita, Hirofumi
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: John Wiley and Sons Inc. 2020
Konular:
Original Research
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7429042/
https://ncbi.nlm.nih.gov/pubmed/32495720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.119.015616
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