Blockade of PAR‐1 Signaling Attenuates Cardiac Hypertrophy and Fibrosis in Renin‐Overexpressing Hypertensive Mice

BACKGROUND: Although PAR‐1 (protease‐activated receptor‐1) exerts important functions in the pathophysiology of the cardiovascular system, the role of PAR‐1 signaling in heart failure development remains largely unknown. We tested the hypothesis that PAR‐1 signaling inhibition has protective effects...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:J Am Heart Assoc
Päätekijät: Yokono, Yoshikazu, Hanada, Kenji, Narita, Masato, Tatara, Yota, Kawamura, Yousuke, Miura, Naotake, Kitayama, Kazutaka, Nakata, Masamichi, Nozaka, Masashi, Kato, Tomo, Kudo, Natsumi, Tsushima, Michiko, Toyama, Yuichi, Itoh, Ken, Tomita, Hirofumi
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: John Wiley and Sons Inc. 2020
Aiheet:
Original Research
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7429042/
https://ncbi.nlm.nih.gov/pubmed/32495720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.119.015616
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