Blockade of PAR‐1 Signaling Attenuates Cardiac Hypertrophy and Fibrosis in Renin‐Overexpressing Hypertensive Mice

BACKGROUND: Although PAR‐1 (protease‐activated receptor‐1) exerts important functions in the pathophysiology of the cardiovascular system, the role of PAR‐1 signaling in heart failure development remains largely unknown. We tested the hypothesis that PAR‐1 signaling inhibition has protective effects...

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Detalhes bibliográficos
Publicado no:J Am Heart Assoc
Main Authors: Yokono, Yoshikazu, Hanada, Kenji, Narita, Masato, Tatara, Yota, Kawamura, Yousuke, Miura, Naotake, Kitayama, Kazutaka, Nakata, Masamichi, Nozaka, Masashi, Kato, Tomo, Kudo, Natsumi, Tsushima, Michiko, Toyama, Yuichi, Itoh, Ken, Tomita, Hirofumi
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7429042/
https://ncbi.nlm.nih.gov/pubmed/32495720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.119.015616
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