Tetrodotoxin‐Sensitive Neuronal‐Type Na(+) Channels: A Novel and Druggable Target for Prevention of Atrial Fibrillation

BACKGROUND: Atrial fibrillation (AF) is a comorbidity associated with heart failure and catecholaminergic polymorphic ventricular tachycardia. Despite the Ca(2+)‐dependent nature of both of these pathologies, AF often responds to Na(+) channel blockers. We investigated how targeting interdependent N...

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Detalhes bibliográficos
Publicado no:J Am Heart Assoc
Main Authors: Munger, Mark A., Olğar, Yusuf, Koleske, Megan L., Struckman, Heather L., Mandrioli, Jessica, Lou, Qing, Bonila, Ingrid, Kim, Kibum, Ramos Mondragon, Roberto, Priori, Silvia G., Volpe, Pompeo, Valdivia, Héctor H., Biskupiak, Joseph, Carnes, Cynthia A., Veeraraghavan, Rengasayee, Györke, Sándor, Radwański, Przemysław B.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7429002/
https://ncbi.nlm.nih.gov/pubmed/32468902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.119.015119
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