Tetrodotoxin‐Sensitive Neuronal‐Type Na(+) Channels: A Novel and Druggable Target for Prevention of Atrial Fibrillation

BACKGROUND: Atrial fibrillation (AF) is a comorbidity associated with heart failure and catecholaminergic polymorphic ventricular tachycardia. Despite the Ca(2+)‐dependent nature of both of these pathologies, AF often responds to Na(+) channel blockers. We investigated how targeting interdependent N...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Am Heart Assoc
Auteurs principaux: Munger, Mark A., Olğar, Yusuf, Koleske, Megan L., Struckman, Heather L., Mandrioli, Jessica, Lou, Qing, Bonila, Ingrid, Kim, Kibum, Ramos Mondragon, Roberto, Priori, Silvia G., Volpe, Pompeo, Valdivia, Héctor H., Biskupiak, Joseph, Carnes, Cynthia A., Veeraraghavan, Rengasayee, Györke, Sándor, Radwański, Przemysław B.
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2020
Sujets:
Original Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7429002/
https://ncbi.nlm.nih.gov/pubmed/32468902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.119.015119
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