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Resolving Peto’s paradox: Modeling the potential effects of size‐related metabolic changes, and of the evolution of immune policing and cancer suppression

The intrinsic risk of cancer increases with body size and longevity; however, big long‐lived species do not exhibit this increase, a contradiction named Peto's paradox. Five hypotheses potentially resolving this paradox were modeled using the multistage model of carcinogenesis. The five hypothe...

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Bibliografiske detaljer
Udgivet i:Evol Appl
Hovedforfatter: Nunney, Leonard
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7428811/
https://ncbi.nlm.nih.gov/pubmed/32821274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/eva.12993
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