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The multiple facets of Peto's paradox: a life-history model for the evolution of cancer suppression

Large animals should have higher lifetime probabilities of cancer than small animals because each cell division carries an attendant risk of mutating towards a tumour lineage. However, this is not observed—a (Peto's) paradox that suggests large and/or long-lived species have evolved effective c...

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Detalhes bibliográficos
Publicado no:Philos Trans R Soc Lond B Biol Sci
Main Authors: Brown, Joel S., Cunningham, Jessica J., Gatenby, Robert A.
Formato: Artigo
Idioma:Inglês
Publicado em: The Royal Society 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4581026/
https://ncbi.nlm.nih.gov/pubmed/26056365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rstb.2014.0221
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