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The multiple facets of Peto's paradox: a life-history model for the evolution of cancer suppression

Large animals should have higher lifetime probabilities of cancer than small animals because each cell division carries an attendant risk of mutating towards a tumour lineage. However, this is not observed—a (Peto's) paradox that suggests large and/or long-lived species have evolved effective c...

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Pubblicato in:Philos Trans R Soc Lond B Biol Sci
Autori principali: Brown, Joel S., Cunningham, Jessica J., Gatenby, Robert A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Royal Society 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4581026/
https://ncbi.nlm.nih.gov/pubmed/26056365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rstb.2014.0221
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