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The multiple facets of Peto's paradox: a life-history model for the evolution of cancer suppression

Large animals should have higher lifetime probabilities of cancer than small animals because each cell division carries an attendant risk of mutating towards a tumour lineage. However, this is not observed—a (Peto's) paradox that suggests large and/or long-lived species have evolved effective c...

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Veröffentlicht in:Philos Trans R Soc Lond B Biol Sci
Hauptverfasser: Brown, Joel S., Cunningham, Jessica J., Gatenby, Robert A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Royal Society 2015
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4581026/
https://ncbi.nlm.nih.gov/pubmed/26056365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rstb.2014.0221
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