Conformational dynamics of a G protein–coupled receptor helix 8 in lipid membranes

G protein–coupled receptors (GPCRs) are the largest and pharmaceutically most important class of membrane proteins encoded in the human genome, characterized by a seven-transmembrane helix architecture and a C-terminal amphipathic helix 8 (H8). In a minority of GPCR structures solved to date, H8 eit...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Dijkman, Patricia M., Muñoz-García, Juan C., Lavington, Steven R., Kumagai, Patricia Suemy, dos Reis, Rosana I., Yin, Daniel, Stansfeld, Phillip J., Costa-Filho, Antonio José, Watts, Anthony
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2020
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7428336/
https://ncbi.nlm.nih.gov/pubmed/32851152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aav8207
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