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Conformational changes of pore helix coupled to gating of TRPV5 by protons
The transient receptor potential channel TRPV5 constitutes the apical entry pathway for transepithelial Ca(2+) transport. We showed that TRPV5 was inhibited by both physiological intra- and extracellular acid pH. Inhibition of TRPV5 by internal protons was enhanced by extracellular acidification. Si...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2005
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1224685/ https://ncbi.nlm.nih.gov/pubmed/16121193 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600795 |
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