Therapeutic Trem2 activation ameliorates amyloid-beta deposition and improves cognition in the 5XFAD model of amyloid deposition

BACKGROUND: Triggering receptor expressed on myeloid cell-2 (TREM2) is a lipid and lipoprotein binding receptor expressed by cells of myeloid origin. Homozygous TREM2 mutations cause early onset progressive presenile dementia while heterozygous, point mutations triple the risk of Alzheimer’s disease...

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Detalhes bibliográficos
Publicado no:J Neuroinflammation
Main Authors: Price, Brittani R., Sudduth, Tiffany L., Weekman, Erica M., Johnson, Sherika, Hawthorne, Danielle, Woolums, Abigail, Wilcock, Donna M.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7427742/
https://ncbi.nlm.nih.gov/pubmed/32795308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-020-01915-0
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