A Novel Siglec-4 Derived Spacer Improves the Functionality of CAR T Cells Against Membrane-Proximal Epitopes

A domain that is often neglected in the assessment of chimeric antigen receptor (CAR) functionality is the extracellular spacer module. However, several studies have elucidated that membrane proximal epitopes are best targeted through CARs comprising long spacers, while short spacer CARs exhibit hig...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Schäfer, Daniel, Henze, Janina, Pfeifer, Rita, Schleicher, Anna, Brauner, Janina, Mockel-Tenbrinck, Nadine, Barth, Carola, Gudert, Daniela, Al Rawashdeh, Wa'el, Johnston, Ian C. D., Hardt, Olaf
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7426717/
https://ncbi.nlm.nih.gov/pubmed/32849600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.01704
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