A Novel Siglec-4 Derived Spacer Improves the Functionality of CAR T Cells Against Membrane-Proximal Epitopes

A domain that is often neglected in the assessment of chimeric antigen receptor (CAR) functionality is the extracellular spacer module. However, several studies have elucidated that membrane proximal epitopes are best targeted through CARs comprising long spacers, while short spacer CARs exhibit hig...

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Detaylı Bibliyografya
Yayımlandı:Front Immunol
Asıl Yazarlar: Schäfer, Daniel, Henze, Janina, Pfeifer, Rita, Schleicher, Anna, Brauner, Janina, Mockel-Tenbrinck, Nadine, Barth, Carola, Gudert, Daniela, Al Rawashdeh, Wa'el, Johnston, Ian C. D., Hardt, Olaf
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Frontiers Media S.A. 2020
Konular:
Immunology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7426717/
https://ncbi.nlm.nih.gov/pubmed/32849600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.01704
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