A Novel Siglec-4 Derived Spacer Improves the Functionality of CAR T Cells Against Membrane-Proximal Epitopes

A domain that is often neglected in the assessment of chimeric antigen receptor (CAR) functionality is the extracellular spacer module. However, several studies have elucidated that membrane proximal epitopes are best targeted through CARs comprising long spacers, while short spacer CARs exhibit hig...

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Vydáno v:Front Immunol
Hlavní autoři: Schäfer, Daniel, Henze, Janina, Pfeifer, Rita, Schleicher, Anna, Brauner, Janina, Mockel-Tenbrinck, Nadine, Barth, Carola, Gudert, Daniela, Al Rawashdeh, Wa'el, Johnston, Ian C. D., Hardt, Olaf
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2020
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7426717/
https://ncbi.nlm.nih.gov/pubmed/32849600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.01704
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