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Engineering combinatorial and dynamic decoders using synthetic immediate-early genes

Many cell- and tissue-level functions are coordinated by intracellular signaling pathways that trigger the expression of context-specific target genes. Yet the input–output relationships that link pathways to the genes they activate are incompletely understood. Mapping the pathway-decoding logic of...

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Detalhes bibliográficos
Publicado no:Commun Biol
Main Authors: Ravindran, Pavithran T., Wilson, Maxwell Z., Jena, Siddhartha G., Toettcher, Jared E.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7426417/
https://ncbi.nlm.nih.gov/pubmed/32792645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-020-01171-1
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