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A live-cell screen for altered Erk dynamics reveals principles of proliferative control

Complex, time-varying responses have been observed widely in cell signaling, but how specific dynamics are generated or regulated is largely unknown. One major obstacle has been that high-throughput screens are typically incompatible with the live-cell assays used to monitor dynamics. Here, we addre...

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書目詳細資料
發表在:Cell Syst
Main Authors: Goglia, Alexander G., Wilson, Maxwell Z., Jena, Siddhartha G., Silbert, Jillian, Basta, Lena P., Devenport, Danelle, Toettcher, Jared E.
格式: Artigo
語言:Inglês
出版: 2020
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7540725/
https://ncbi.nlm.nih.gov/pubmed/32191874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cels.2020.02.005
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