Repurposing Pyramax®, quinacrine and tilorone as treatments for Ebola virus disease

We have recently identified three molecules (tilorone, quinacrine and pyronaridine tetraphosphate) which all demonstrated efficacy in the mouse model of infection with mouse-adapted Ebola virus (EBOV) model of disease and had similar in vitro inhibition of an Ebola pseudovirus (VSV-EBOV-GP), suggest...

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Vydáno v:Antiviral Res
Hlavní autoři: Lane, Thomas R., Dyall, Julie, Mercer, Luke, Goodin, Caleb, Foil, Daniel H., Zhou, Huanying, Postnikova, Elena, Liang, Janie Y., Holbrook, Michael R., Madrid, Peter B., Ekins, Sean
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier B.V. 2020
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7425680/
https://ncbi.nlm.nih.gov/pubmed/32798602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.antiviral.2020.104908
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