Cathepsin B/ SAPC inhibition deregulates apoptosis-related proteins in neuronal cells exposed to supernatants from HIV-infected macrophages

Monocytes infected with Human immunodeficiency virus 1 (HIV-1) can cross the blood-brain barrier to the central nervous system facilitating neuronal damage. Brain monocyte-derived macrophages can induce HIV neurocognitive disorders (HAND) by releasing neurotoxic factors. One of these secreted factor...

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Vydáno v:J Biomol Tech
Hlavní autoři: Melendez, Loyda, PhD, Zenon-Melendez, Camille, MS, Lima, Abiel Roche, Carrasquillo-Carrión, Kelvin, Cantres-Rosario, Yadira, BS
Médium: Artigo
Jazyk:Inglês
Vydáno: Association of Biomolecular Resource Facilities 2020
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Poster Abstracts
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7424844/
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