Oncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia

Interleukin 7 (IL-7) and its receptor, formed by IL-7Rα (encoded by IL7R) and γc, are essential for normal T-cell development and homeostasis. Here we show that IL7R is an oncogene mutated in T-cell acute lymphoblastic leukemia (T-ALL). We find that 9% of individuals with T-ALL have somatic gain-of-...

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Publicado no:Nat Genet
Main Authors: Zenatti, Priscila P, Ribeiro, Daniel, Li, Wenqing, Zuurbier, Linda, Silva, Milene C, Paganin, Maddalena, Tritapoe, Julia, Hixon, Julie A, Silveira, André B, Cardoso, Bruno A, Sarmento, Leonor M, Correia, Nádia, Toribio, Maria L, Kobarg, Jörg, Horstmann, Martin, Pieters, Rob, Brandalise, Silvia R, Ferrando, Adolfo A, Meijerink, Jules P, Durum, Scott K, Yunes, J Andrés, Barata, João T
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7424552/
https://ncbi.nlm.nih.gov/pubmed/21892159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.924
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