New anti-IL-7Rα monoclonal antibodies show efficacy against T cell acute lymphoblastic leukemia in pre-clinical models

Pediatric T cell acute lymphoblastic leukemia (T-ALL) cells frequently contain mutations in the interleukin-7 (IL-7) receptor pathway or respond to IL-7 itself. To target the IL-7 receptor on T-ALL cells, murine monoclonal antibodies (MAbs) were developed against the human IL-7Rα chain and chimerize...

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Publicado en:Leukemia
Autores principales: Hixon, Julie A., Andrews, Caroline, Kashi, Lila, Kohnhorst, Casey L., Senkevitch, Emilee, Czarra, Kelli, Barata, Joao T., Li, Wenqing, Schneider, Joel P., Walsh, Scott T. R., Durum, Scott K.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8132108/
https://ncbi.nlm.nih.gov/pubmed/31439943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41375-019-0531-8
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