The significance of PTEN and AKT aberrations in pediatric T-cell acute lymphoblastic leukemia

BACKGROUND: PI3K/AKT pathway mutations are found in T-cell acute lymphoblastic leukemia, but their overall impact and associations with other genetic aberrations is unknown. PTEN mutations have been proposed as secondary mutations that follow NOTCH1-activating mutations and cause cellular resistance...

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Bibliographic Details
Main Authors: Zuurbier, Linda, Petricoin, Emanuel F., Vuerhard, Maartje J., Calvert, Valerie, Kooi, Clarissa, Buijs-Gladdines, Jessica G.C.A.M., Smits, Willem K., Sonneveld, Edwin, Veerman, Anjo J.P., Kamps, Willem A., Horstmann, Martin, Pieters, Rob, Meijerink, Jules P.P.
Format: Artigo
Language:Inglês
Published: Ferrata Storti Foundation 2012
Subjects:
Original Articles and Brief Reports
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3436243/
https://ncbi.nlm.nih.gov/pubmed/22491738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2011.059030
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