Recurrent NR3C1 Aberrations at First Diagnosis Relate to Steroid Resistance in Pediatric T-Cell Acute Lymphoblastic Leukemia Patients

The glucocorticoid receptor NR3C1 is essential for steroid-induced apoptosis, and deletions of this gene have been recurrently identified at disease relapse for acute lymphoblastic leukemia (ALL) patients. Here, we demonstrate that recurrent NR3C1 inactivating aberrations—including deletions, missen...

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Publicado en:Hemasphere
Main Authors: van der Zwet, Jordy C. G., Smits, Willem, Buijs-Gladdines, Jessica G. C. A. M., Pieters, Rob, Meijerink, Jules P. P.
Formato: Artigo
Idioma:Inglês
Publicado: Lippincott Williams & Wilkins 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7755520/
https://ncbi.nlm.nih.gov/pubmed/33364552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/HS9.0000000000000513
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