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The significance of PTEN and AKT aberrations in pediatric T-cell acute lymphoblastic leukemia
BACKGROUND: PI3K/AKT pathway mutations are found in T-cell acute lymphoblastic leukemia, but their overall impact and associations with other genetic aberrations is unknown. PTEN mutations have been proposed as secondary mutations that follow NOTCH1-activating mutations and cause cellular resistance...
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| Auteurs principaux: | , , , , , , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Ferrata Storti Foundation
2012
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3436243/ https://ncbi.nlm.nih.gov/pubmed/22491738 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2011.059030 |
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