Inhibition of the ROS-EGFR Pathway Mediates the Protective Action of Nox1/4 Inhibitor GKT137831 against Hypertensive Cardiac Hypertrophy via Suppressing Cardiac Inflammation and Activation of Akt and ERK1/2

Oxidative stress, inflammation, and hypertension constitute a self-perpetuating vicious circle to exacerbate hypertension and subsequent hypertensive cardiac hypertrophy. NADPH oxidase (Nox) 1/4 inhibitor GKT137831 alleviates hypertensive cardiac hypertrophy in models of secondary hypertension; howe...

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Detalhes bibliográficos
Publicado no:Mediators Inflamm
Main Authors: Zeng, Si-yu, Yan, Qiu-jiang, Yang, Li, Mei, Qing-hua, Lu, Hui-qin
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7424508/
https://ncbi.nlm.nih.gov/pubmed/32831633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2020/1078365
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