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Predicting the chemical space of fungal polyketides by phylogeny-based bioinformatics analysis of polyketide synthase-nonribosomal peptide synthetase and its modification enzymes

Fungal polyketide synthase (PKS)–nonribosomal peptide synthetase (NRPS) hybrids are key enzymes for synthesizing structurally diverse hybrid natural products (NPs) with characteristic biological activities. Predicting their chemical space is of particular importance in the field of natural product c...

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Publicado en:Sci Rep
Main Authors: Minami, Atsushi, Ugai, Takahiro, Ozaki, Taro, Oikawa, Hideaki
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2020
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7421883/
https://ncbi.nlm.nih.gov/pubmed/32782278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-70177-w
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