The Periostin/Integrin-αv Axis Regulates the Size of Hematopoietic Stem Cell Pool in the Fetal Liver

We earlier showed that outside-in integrin signaling through POSTN-ITGAV interaction plays an important role in regulating adult hematopoietic stem cell (HSC) quiescence. Here, we show that Itgav deletion results in increased frequency of phenotypic HSCs in fetal liver (FL) due to faster proliferati...

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Veröffentlicht in:Stem Cell Reports
Hauptverfasser: Biswas, Atreyi, Roy, Irene M., Babu, Prathibha C., Manesia, Javed, Schouteden, Sarah, Vijayakurup, Vinod, Anto, Ruby John, Huelsken, Joerg, Lacy-Hulbert, Adam, Verfaillie, Catherine M., Khurana, Satish
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7419718/
https://ncbi.nlm.nih.gov/pubmed/32735820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2020.06.022
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