Outside-in integrin signalling regulates haematopoietic stem cell function via Periostin-Itgav axis

Integrins play an important role in haematopoietic stem cell (HSC) maintenance in the bone marrow niche. Here, we demonstrate that Periostin (Postn) via interaction with Integrin-αv (Itgav) regulates HSC proliferation. Systemic deletion of Postn results in peripheral blood (PB) anaemia, myelomonocyt...

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Bibliografske podrobnosti
izdano v:Nat Commun
Main Authors: Khurana, Satish, Schouteden, Sarah, Manesia, Javed K., Santamaria-Martínez, Albert, Huelsken, Joerg, Lacy-Hulbert, Adam, Verfaillie, Catherine M.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2016
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5146274/
https://ncbi.nlm.nih.gov/pubmed/27905395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13500
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