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Outside-in integrin signalling regulates haematopoietic stem cell function via Periostin-Itgav axis
Integrins play an important role in haematopoietic stem cell (HSC) maintenance in the bone marrow niche. Here, we demonstrate that Periostin (Postn) via interaction with Integrin-αv (Itgav) regulates HSC proliferation. Systemic deletion of Postn results in peripheral blood (PB) anaemia, myelomonocyt...
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| Publicat a: | Nat Commun |
|---|---|
| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group
2016
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5146274/ https://ncbi.nlm.nih.gov/pubmed/27905395 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13500 |
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