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UTX Regulates Human Neural Differentiation and Dendritic Morphology by Resolving Bivalent Promoters

UTX, a H3K27me3 demethylase, plays an important role in mouse brain development. However, so little is known about the function of UTX in human neural differentiation and dendritic morphology. In this study, we generated UTX-null human embryonic stem cells using CRISPR/Cas9, and differentiated them...

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Detalhes bibliográficos
Publicado no:Stem Cell Reports
Main Authors: Tang, Qing-Yuan, Zhang, Shuang-Feng, Dai, Shang-Kun, Liu, Cong, Wang, Ying-Ying, Du, Hong-Zhen, Teng, Zhao-Qian, Liu, Chang-Mei
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7419705/
https://ncbi.nlm.nih.gov/pubmed/32679064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2020.06.015
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