SIV and Mycobacterium tuberculosis synergy within the granuloma accelerates the reactivation pattern of latent tuberculosis

Human immunodeficiency virus infection is the most common risk factor for severe forms of tuberculosis (TB), regardless of CD4 T cell count. Using a well-characterized cynomolgus macaque model of human TB, we compared radiographic, immunologic and microbiologic characteristics of early (subclinical)...

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Опубликовано в: :PLoS Pathog
Главные авторы: Diedrich, Collin R., Rutledge, Tara, Maiello, Pauline, Baranowski, Tonilynn M., White, Alexander G., Borish, H. Jacob, Karell, Paul, Hopkins, Forrest, Brown, Jessica, Fortune, Sarah M., Flynn, JoAnne L., Ambrose, Zandrea, Lin, Philana Ling
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2020
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7419014/
https://ncbi.nlm.nih.gov/pubmed/32730321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008413
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