SIV and Mycobacterium tuberculosis synergy within the granuloma accelerates the reactivation pattern of latent tuberculosis

Human immunodeficiency virus infection is the most common risk factor for severe forms of tuberculosis (TB), regardless of CD4 T cell count. Using a well-characterized cynomolgus macaque model of human TB, we compared radiographic, immunologic and microbiologic characteristics of early (subclinical)...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Diedrich, Collin R., Rutledge, Tara, Maiello, Pauline, Baranowski, Tonilynn M., White, Alexander G., Borish, H. Jacob, Karell, Paul, Hopkins, Forrest, Brown, Jessica, Fortune, Sarah M., Flynn, JoAnne L., Ambrose, Zandrea, Lin, Philana Ling
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7419014/
https://ncbi.nlm.nih.gov/pubmed/32730321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008413
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